714X is the invented name of Triméthylaminohydroxybicycloheptane chloride.Chemical formula
714X is an isotonic solution at physiological pH (7) containing nitrogen as the main active ingredient, camphor as a vehicle, or a nitrogenated derivative of camphor, at a level of 0.09 mg/ml (complying with the pharmaceutical industry’s norms of injectable solutions), mineral salts, and 18 different trace elements (metallic elements), measured in parts per million, and magnesium at a level of 6.5 ppm. these trace elements, even in trace amounts, do have a biological significance.
The level of sodium chloride (NaCl) is estimated at 8.2g/litre.
A plasma emission spectrometry study identifies the 18 following elements measured by the following parts per million):
Aluminum < 0.5 ppm Calcium 0.5 ppm Mercury < 1.0 ppm
Antimoine < 1.0 ppm Chrome < 0.1 ppm Molybdenum < 1.0 ppm
Arsenic < 1.0 ppm Cobalt < 1.0 ppm Nickel < 0.1 ppm
Baryum 0.7 ppm Cuivre 0.01 ppm Phosphore < 5.0 ppm
Bore < 0.05 ppm Fer < 0.1 ppm Plomb < 1.0 ppm
Cadmium < 0.05 ppm Magnésium 6.5 ppm Zinc 2.0 ppmConclusionThe absence of proteins and immunoglobulins
shows that this is not an immune serum prepared after injection to animals. 714X is not a vaccine. There is no risk of allergies or anaphylactic shock.
The presence of sodium chloride
at a level of 8.2 g / liter shows that this is an isotonic solution with a pH of 7 (physiological solution). This solution complies with norms for injectable solutions of the pharmaceutical industry.
A mass spectrometry coupled with a chromatography reveals the presence of camphor
or trimethyl-1.7.7 bicyclo (2.2.1.) heptanone-2
whose concentration we measured as 0.09 mg / ml (90 ppm). A nitrogenated compound
and hydrochloric acid
were also identified.
The comparative study using camphoroxime shows that this molecule does not exist as such in the analyzed sample of 714X. The precise nature of the nitrogenated compound contained in 714X could not be clearly identified.Eighteen metals (metallic elements) were measured
. They were all found at trace levels
(parts per million) and considered to be of no biological significance
, except for magnesium which at 6.5 ppm was too low to be given a therapeutic property. (This is the opinion of the private laboratory. However, the manufacturer claims that these trace elements, even in trace amounts, do have a biological significance)Summary of the chemical analysis
Ultimately, 714X is an isotonic solution at physiological pH (7) containing camphor
or a nitrogenated derivative of camphor, at a level of 0.09 mg/ml, complying with the pharmaceutical industry’s norms of injectable solutions
714X belongs to a health products category that acts upon natural defenses including the immune function.
Depending on the circumstances, 714X acts on a severely weakened immune system (by strengthening it) or on an overactive immune system (by slowing it down). For this reason, 714X is recognized as an immuno modulator.
Moreover, to date, 3 patents confirm that 714X is an immunomodulator
Canadian Patent: 2010.CA02297998
European Patent: 2005.EP1251841-B1
American Patent: 2003-6-596-295Research Report – Immunologic test applied to 714X
(vitro Effects of 714X on mononuclear cells of peripheral blood)Sponsor:
Diane Van Alstyne, Ph.D.
#23-130 MacPherson Ave.
Toronto, Ontario, CANADA M5R 1W8Period of Experimentation:
March 1999, Boston, Massachusetts, USAResults and conclusions
Peripheral blood mononuclear cells and monocytes exposed to 714X in vitro show the following effects:
Over 50% activation and / or cell differentiation, resulting in morphological changes and modification of cell adherance on microwell plates.
An atypical and immediate intracellular accumulation of Ca+2 ions in monocytes, and none in the control sample.
Induction of cytokines, including tumor necrosis factor alpha (TNF-α), interleukin-1β, -6, 8, and an increase in the intracellular level of cytokine-specific mRNAs including 362 bp for TNF-α, 330 bp for IL-1β, 496 bp for IL-6, and 407 bp for IL-8. Structural analysis of molecular components contained in 714X (compared to the inactive control product) reveals the presence of two nitrogen-containing compounds derived from camphor, molecular weight of 169.5 and 151.25, unique to 714X
Based on the foregoing data, the sponsor suggests that 714X contains at least one component which acts as a substance that promotes the induction of cytokine in vitro and has the following characteristics:
Ability to bind to receptors to initiate activity;
Possession of a cell affinity, and
Possession of intrinsic activity.
The results clearly demonstrate that 714X is a strong activator of monocytes and / or macrophages and induces the secretion of proinflammatory cytokines including tumor necrosis factor (TNF-α) and interleukins IL-1β, IL-6 and IL-8. Monocytes / macrophages play a key role in immune defense. Macrophages represent a major recognition system for foreign cells, including tumor cells, and an important source of cytokines with immuno-modulatory properties and antitumor activities (including proinflammatory cytokines
TNF-α, IL-1β, IL-6 and IL-8). These data provide scientific evidence to 714X’s immunomodulatory role.
It is believed that the 714X enhances the immune response and plays a role in the removal of the tumor cell. The results appear to support this theory by suggesting that induction of proinflammatory cytokines represent at least one mechanism responsible for anti-tumor activity in vivo of 714X.
Assurance of Quality Control:
Data reviewed and report provided by researcher Diane Van Alstyne, Ph.D.
Report published 25 August 2000